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Eunnara Cho
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David Eickmeyer, MSc
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Tatiana Kozbenko
MSc candidate Tatiana is our rocket scientist! She is building space-flight relevant AOPs (adverse outcome pathways). Specifically, she is collecting and analyzing data to support the link ionizing radiation in space and resulting cardiovascular disease, ocular disorders, bone loss and cognitive effects. Tatiana is also passionate about science communication and has completed the illustrations for our GReAT website!
Co-Supervisor: Vinita Chauhan, Health Canada 
Geronimo Parodi-Matteo
PhD Student Geronimo is conducting research to determine the toxicity of plasticizers that are used to replace Bisphenol A (BPA), a widely studied endocrine disrupting chemical. Canada was the first country to take regulatory action on BPA. Many new chemicals have since emerged as replacements to BPA and Geronimo is using high-throughput transcriptomics to study the estrogenic activity and potency of these replacements. He's also exploring how these chemicals interact in mixtures to cause toxicity and inform regulatory decision-making. His work is helping to catalyze the modernization of human health risk assessment.
Co-supervisor: Ella Atlas, Health Canada and adjunct at uOttawa |
Annette Dodge
MSc candidate Annette's research focuses on the application of new in vivo assays in genetic toxicology. Specifically, she is working on applying Duplex Sequencing™ as a novel method for the analysis of mutation induction and spectra in tissues exposed to toxic substances. This work aims to investigate if Duplex Sequencing could serve as a new standard for in vivo mutagenicity testing that obviates the need for transgenic organisms.
Co-supervisor: Francesco Marchetti, Health Canada and adjunct at Carleton 
David Schuster
PhD Student David’s project works towards validation of a novel error-corrected sequencing method called Duplex Sequencing (DS). He is comparing mutation frequencies and spectra measured by DS to conventional mutagenicity endpoints. His project involves many international collaborators to potentially establish DS as the new gold standard for in vivo mutagenicity testing.
Co-supervisor: Francesco Marchetti, Health Canada, and adjunct at Carleton |
Jonatan Axelsson
Visiting scientist Jonatan is a physician who is visiting the GReAT lab from Sweden. His research focuses on the role of environmental and life-style related factors that may mediate germ cell mutation frequencies and spectra in males as possible explanations behind diseases in offspring. He is studying mutation using DS in both mice and humans to explore this possibility.
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Hyojin Lee
Post-doctoral fellow Hyojin's research in the GReAT lab explores the underlying molecular mechanisms of toxicity and potency of per- and poly-fluorinated substances (PFAS) both individually and when present in mixtures. She will be determining benchmark dose (BMD) /point-of-departure (POD) of PFASs using the zebrafish model and transcriptomics and performing class-based hazard assessments of PFAS mixture.
Supervisors: Hyojin has three supervisors for this complex multi-disciplinary project. Carole Yauk and Jan Mennigen (uOttawa), and Jason O’Brien from Environment and Climate Change Canada |
Gone on to other great things
Anthony Reardon, post-doctoral fellow
Anthony was doing research to understand the toxicological effects of per- and poly-fluoroalkyl substances (PFAS), often referred to as 'forever chemicals'. With over 4,000 in the environment, he used transcriptomic profiling technologies to understand the dose-response behaviours of untested PFAS on their own and in mixtures.
Co-supervisor: Ella Atlas, Health Canada and adjunct uOttawa
Anthony is now a regulatory scientist in the Existing Substances and Risk Assessment Bureau at Health Canada. He's putting the newest approaches in genomics and in vitro tests into action in regulatory decision making to protect human health.
Anthony was doing research to understand the toxicological effects of per- and poly-fluoroalkyl substances (PFAS), often referred to as 'forever chemicals'. With over 4,000 in the environment, he used transcriptomic profiling technologies to understand the dose-response behaviours of untested PFAS on their own and in mixtures.
Co-supervisor: Ella Atlas, Health Canada and adjunct uOttawa
Anthony is now a regulatory scientist in the Existing Substances and Risk Assessment Bureau at Health Canada. He's putting the newest approaches in genomics and in vitro tests into action in regulatory decision making to protect human health.
Kundai Mufara, volunteer
Kundai was a volunteer helping us to build Adverse Outcome Pathways linking chemically induced DNA damage to downstream effects like chromosome breaks and mutations. She's now a science content writer for an environmental software company, combining her love of science, writing and communication.
http://kuecreates.com/professional-portfolio/
